作者单位
摘要
上海交通大学生物医学工程学院,上海 200240
光学相干层析成像(OCT)能够无损获得微米级空间分辨率的样品截面信息,在眼科、血管内科等临床诊疗研究和应用中起到了重要的作用。利用OCT测量光场的幅度可以获得样本的三维结构信息,如眼底视网膜的分层结构,但对组织特异性、血流、力学特性等功能信息的作用有限。基于相位、偏振态、波长等光场参量的OCT功能成像技术应运而生,如多普勒OCT、OCT弹性成像、偏振敏感OCT、可见光OCT等。其中,基于光场幅度动态变化的OCT功能成像技术具有显著的鲁棒性和系统复杂度优势,已经在临床无标记血管造影中获得成功。此外,应用于三维血流流速测量的动态光散射OCT、具有无标记组织/细胞特异性显示能力的动态OCT、能够监控热物理治疗温度场的OCT温度层析成像等,已经成为了OCT功能成像的技术前沿。综述基于光场幅度动态变化的OCT功能成像技术的原理、实现和应用,分析了所面临的技术挑战,并展望了未来发展方向。
光学相干层析成像 功能成像 光场幅度动态变化 动态光散射 
激光与光电子学进展
2024, 61(2): 0211018
Author Affiliations
Abstract
International Collaborative Laboratory of 2D Materials for Optoelectronic Science & Technology of Ministry of Education, Engineering Technology Research Center for 2D Material Information Function Devices and Systems of Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
An opposite-chirped frequency-domain optical parametric amplification (OC-FOPA) design is demonstrated and numerically verified. This scheme combines both an ultrabroad seeding generation and the subsequent effective amplification in one single optical parametric amplification stage. Based on a slightly asymmetrical 4-f optical system, the spectral contents of both pump and signal waves are spectrally dispersed with opposite spatial chirps, to broaden the initial idler seeding. Via a properly designed fan-out periodically poled LiNbO3 chip, nearly perfect quasi phase matching can be realized across the full spectrum, whereby each individual spectral pair precisely maps to its required grating period. Full-dimensional simulations based on commercial ~110 fs (FWHM) near-infrared (near-IR) lasers at 790 and 1030 nm are quantitatively discussed, and few-cycle mid-IR laser pulses (~60 fs at 3.4 μm) plus a high conversion efficiency exceeding 50% are theoretically predicted. By means of a high-power pump source, the OC-FOPA scheme can be also applied to directly produce high-intensity carrier-envelope-phase-stabilized mid-IR idler pulses.
(190.4970) Parametric oscillators and amplifiers (320.7110) Ultrafast nonlinear optics (320.7160) Ultrafast technology. 
Photonics Research
2017, 5(6): 06000669
Author Affiliations
Abstract
Key Laboratory for Laser Plasmas (Ministry of Education) and the Department of Physics, Shanghai Jiao Tong University, Shanghai 200240, China
We briefly review the development of gain-switched rare-earth-doped fiber lasers and their applications in wavelength conversion to mid-IR, supercontinuum generation, and medicine in recent years. We illustrate the similarities between gain-switching and Q-switching techniques that will provide tools for the design and optimization of the gain-switched fiber lasers. From the nature of the gain-switched fiber lasers, benefits of this kind of lasers to 2-μm region and in-band-pumped (two-level system) laser systems are obvious. Advantages of in-band-pumped 2-μm lasers are discussed and analyzed with a simple numerical simulation in terms of Tm-doped fiber lasers. We also propose the key factors in the development of the gain-switched fiber lasers and predict the future tendency.
Fiber optics infrared Laser theory Lasers fiber Lasers pulsed 
Photonics Research
2013, 1(1): 01000052

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